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M94A2638.TXT
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1994-10-25
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Document 2638
DOCN M94A2638
TI Neurological manifestation in parenterally HIV-1 infected children in
Russia.
DT 9412
AU Rakhmanova A; Fomin J; Chernykh M; Popova I; Burova N; Fomina M; Russian
Clinical HIV-AIDS center, St.-Petersburg.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):259 (abstract no. PB0466). Unique
Identifier : AIDSLINE ICA10/94369937
AB OBJECTIVE: The prevalence of central nervous system (CNS) disease in
HIV-1 infected children have been reported in several series to vary
between 8% and 62%. The aim was to describe CNS diseases in russian
children infected HIV-1 by parenteral route. METHODS: 76 HIV-1 infected
children were enrolled in surveillance from 1/91 to 10/93 year. The most
of them were in 5-7 year age group. All children were infected HIV-1
five years ago in hospitals where they were with any serious illnesses.
Clinical histories were reviewed to collect data. At time of the
analyses 45 patients had ARC, 16--AIDS, 8--have died. RESULTS: Of 76
enrolled children 64 (81.5%) have had signs of CNS disease (delay
psychomotor and language developing, neurological signs). Fifty one from
those 64 patients before expose to HIV have had multiply risk factor for
encephalopathy due to events in perinatal period (prematurity, in utero
infections, severe hypoxic injury). 8 (12.5%) patients have had
HIV-related encephalopathy diagnosed by clinical exams and computed
tomographic scans. 6 children with HIV-related CNS disease were
long-treated by oral Retrovir (Wellcome) and have surviving more than 2
years without progression CNS symptoms. Two other patients have not been
treated and died in 6-9 month after HIV-related encephalopathy have been
diagnosed. CONCLUSION: 1. The diagnose of HIV-related CNS disease was
difficult for multiply risk factor preceding HIV infection. 2. Retrovir
was useful for treatment HIV-related encephalopathy in children.
DE AIDS Dementia Complex/*DIAGNOSIS Child Child, Preschool Follow-Up
Studies Human HIV Infections/*DIAGNOSIS/TRANSMISSION *HIV-1
*Neurologic Examination Risk Factors Russia MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).